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Benzodiazepines are best when applied early after a seizure begins, on account of alterations at synapses that degrade GABA signaling more than time12,13Monitor Closely (two)diazepam will enhance the degree or effect of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism.teduglutide raises levels of diazepam by Other (se